||Jeffrey L. Ebersole
|Appointment Start Date:
|Appointment End Date:
|Area of Specialty:
||B cell biology and antibodies in secretory immunity and periodontal immunobiology. Primary research emphasis is in the development, specificity and functional abilities of antibodies in the oral cavity.
||Alvin L. Morris Professor of Oral Health Research
Director, Center for Oral Health Research
Associate Dean for Research
B.S., Biology, Temple University
Ph.D., Microbiology, University of Pittsburgh
||IADR Microbiology and Immunology Group
American Association of Dental Research
International Association of Dental Research
American Association for the Advancement of Science
|Primary Research Focus:
||Our laboratory's emphasis is the determination of host responses associated with bacterial colonization/infection by selected periodontopathic bacteria. Our emphasis with respect to these polymicrobial infections and responses to biofilms have been: (1) to characterize the use of a murine model for studies delineating the bacterial and host components that contribute to both soft and hard tissue destruction caused by these pathogens; (2) to utilize the nonhuman primate model of periodontitis to evaluate host-bacterial interactions in the chronic inflammatory disease; (3) to delineate the macromolecules of these bacteria that elicit the production/secretion of various host inflammatory mediators from non-immune cells (ie. gingival fibroblasts, epithelial cells); and, (4) to provide translational evidence on biologic links between oral infections and systemic diseases.
||Development and implementation of ELISA for studies of humoral immune responses in oral biology.
Identification of parameters for induction of secretory immune responses in the oral cavity.
Development of technology for evaluation of antibody and mediators in gingival crevicular fluid as diagnostic/prognostic risk markers for periodontitis.
Identification of systemic inflammatory mediator changes in periodontitis patients.
Biologic characteristics of selected oral pathogens using in vitro and in vivo models.
Delineation of the use of nonhuman primate models for evaluating infections and host responses in the oral cavity.
||Holt, S.C. and J.L. Ebersole. 2005. The oral spirochetes: Their ecology and role in oral pathogenesis. Horizon Scientific Text, Ed. J. Radolf, In press.
Holt, SC; Ebersole, JL. 2005. Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitis. Periodontol 2000. 38: 72-122.
Ebersole, JL Meka, A, Stromberg, A, Saunders, C and Kesavalu LK. 2005. Host gene expression in local tissues in response to periodontal pathogens. Oral Biosci Med 2:175-184.