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Name: Leonidas  Bachas
Position Type: Professorship
Appointment Start Date: 01/01/03
Appointment End Date: 06/30/07
Area of Specialty: Analytical and Biological Chemistry
Summary Vita: B.S., University of Athens, Athens, Greece, July 1981; M.S., Analytical Chemistry, University of Michigan, Ann Arbor, Michigan, August 1983; M.S., Engineering, University of Michigan, Ann Arbor, Michigan, December 1985; Ph.D., Bioanalytical Chemistry, University of Michigan, Ann Arbor, Michigan, January 1986; Postdoctoral Research Fellow, Department of Chemistry, University of Michigan, January 1986 - July 1986; Research Trainee, Analytical Chemistry Laboratory, Division of Chromatography, DSM Research, Geleen, The Netherlands, Summer 1979; Undergraduate Research Assistant, Environmental Research Group (Inorg. Chem. Lab.), University of Athens, 1977-81; Teaching Assistant, Department of Chemistry, University of Michigan, 1981-83; Research Assistant, Department of Chemistry, University of Michigan, 1982-85; Postdoctoral Research Fellow, Department of Chemistry, University of Michigan, 1/86-7/86; Assistant Professor, Department of Chemistry, University of Kentucky, 8/86-6/91; Associate Professor, Department of Chemistry, University of Kentucky, 7/91-6/95; Associate, Center of Membrane Sciences, University of Kentucky, 1987-present; Professor, Biological and Analytical Chemistry, Department of Chemistry, University of Kentucky, 1995-present; Director, IGERT Program and Integrated Sensing Architectures, 8/98-8/04; Associate Director, University of Kentucky Superfund Program, 3/02-present; Associate Dean, Research and Academic Programs, College of Arts and Sciences, 1/2004-present.
Highest Degree: Ph.D.
Professional Affiliations: American Chemical Society; American Association for Clinical Chemistry; Analytica Chimica Acta; Kentucky Academy of Science (Committee on Science and Government); Microchimica Acta, Editorial Board, 2002-05; Sensors Letters, Editorial Board, 2003-04; Talanta, Editorial Board, 2004-06; Society for Electroanalytical Chemistry, Member of the Board of Directors, 2004-09; Applied Biochemistry and Biotechnology, Editorial Board, 2004-present.
Primary Research Focus: Development and evaluation of analytical methodologies (competitive binding assays, recombinant DNA techniques, biosensors, fiber optic sensors and ion-selective electrodes) for the determination of biochemically and environmentally important compounds (e.g., proteins, enzymes, vitamins and drugs).
Key Contributions: Ground-breaking laboratory work in the area of biosensing, including 7 patents.
Publications: B. J. Hinds, N. Chopra, T. Rantell, R. Andrews, V. Gavalas and L. G. Bachas, "Aligned Multiwalled Carbon Nanotube Membranes," Science, 303, 62-65 (2004); P. Nednoor, M. Capaccio, V. G. Gavalas, M. S. Meier, J. E. Anthony and L. G. Bachas, "Hybrid Nanoparticles Based on Organized Protein Immobilization on Fullerenes," Bioconjugate Chem., 15, 12-15 (2004); D. K. Ahuja, V. G. Gavalas, L. G. Bachas and D. Bhattacharyya, "Aqueous-Phase Dechlorination of Toxic Chloroethylenes by Vitamin B12 Cobalt Center: Conventional and Polypyrrole Film-Based Electrochemical Reactions," Ind. Eng. Chem. Res., 43, 1049-1055 (2004); R. B. Iyer and L. G. Bachas "Enzymatic Recycling of NADPH at High Temperature Utilizing a Thermostable Glucose-6-phosphate Dehydrogenase from Bacillus stearothermophilus," J. Mol. Cat. B: Enzymatic, 28, 1-5 (2004); B. Hennig, M. Toborek, L. G. Bachas and W. A. Suk, "Emerging Issues: Nutritional Awareness in Environmental Toxicology," J. Nutr. Biochem., 15, 194-195 (2004); V. G. Gavalas, S. A. Law, J. C. Ball, R. Andrews and L. G. Bachas, "Carbon Nanotube Aqueous Sol-Gel Composites: Enzyme-Friendly Platforms for the Development of Stable Biosensors," Analytical Biochemistry, 329, 247-252 (2004); E. A. Moschou, S. F. Peteu, L. G. Bachas, M. J. Madou and S. Daunert, "Artificial Muscle Material with Fast Electroactuation Under Neutral pH Conditions," Chem. Mater., 16, 2499-2502 (2004); K. M. L. May, Y. Wang, L. G. Bachas and K. W. Anderson, "Development of a Whole-Cell-Based Biosensor for Detecting Histamine as a Model Toxin," Anal. Chem., 76, 4156-4161 (2004); J. S. Lenihan, V. Gavalas, J. Wang, R. Andrews and L. G. Bachas, "Protein Immobilization on Carbon Nanotubes Through a Molecular Adapter," J. Nanosci. Nanotech., 4, 600-604 (2004); L. G. Puckett, E. Dikici, S. Lai, M. Madou, L. G. Bachas and S. Daunert, "Investigation Into the Applicability of the Centrifugal Microfluidics Platform for the Development of Protein-Ligand Binding Assays Incorporating Enhanced Green Fluorescent Protein as a Fluorescent Reporter," Anal. Chem., 76, 7263-7268 (2004); D. E. Meyer, K. Wood, L. G. Bachas and D. Bhattacharyya, "Degradation of Chlorinated Organics by Membrane-Immobilized Nanosized Metals," Environ. Progr., 23, 232-242 (2004); D. Bhattacharyya, D. Meyer, L. Bachas and S. M. C. Ritchie, "Membrane-Based Nanostructured Metals for Reductive Degradation of Hazardous Organics," ACS Symp. Ser., 890, 256-267 (2005); I. H. A. Badr, J. Feiler and L. G. Bachas, "Response Behavior of Sodium-Selective Electrodes Modified by Surface Attachment of the Anticoagulant Polysaccharides Heparin and Chondroitin Sulfate," Talanta, 65, 261-266 (2005); L. G. Puckett, J. K. Lewis, A. Urbas, X. Cui, D. Gao and L. G. Bachas, "Magnetoelastic Transducers for Monitoring Coagulation, Clot Inhibition, and Fibrinolysis," Biosens. Bioelectron., 20, 1737-1743 (2005); M. Capaccio, V. G. Gavalas, M. S. Meier, J. E. Anthony and L. G. Bachas, "Coupling Biomolecules to Fullerenes Through a Molecular Adapter," Bioconj. Chem., 16, 241-244 (2005); J. D. Ehrick, S. K. Deo, T. W. Browning, L. G. Bachas, M. J. Madou and S. Daunert, "Genetically Engineered Proteins in Hydrogels Tailors Stimuli-Responsive Characteristics," Nat. Mater., 4, 298-302 (2005); A. Makkuni, L. G. Bachas, R. S. Varma, S. K. Sikdar and D. Bhattacharyya, "Aqueous and Vapor Phase Mercury Sorption by Inorganic Oxide Materials Functionalized with Thiols and Poly-Thiols," Clean Technol. Environ. Policy, 7, 87-96 (2005); K. M. L. May, A. Vogt, L. G. Bachas and K. W. Anderson, "Vascular Endothelial Growth Factor as a Biomarker for the Early Detection of Cancer Using a Whole Cell-Based Biosensor," Anal. Bioanal. Chem., 382, 1010-1016 (2005); P. Nednoor, N. Chopra, V. Gavalas, L. G. Bachas and B. J. Hinds, "Reversible Biochemical Switching of Ionic Transport Through Aligned Carbon Nanotube Membranes," Chem. Mater., 17, 3595-3599 (2005); Y.-C. Li, L. G. Bachas and D. Bhattacharyya, "Kinetic Studies of Trichlorophenol Destruction by Chelate-Based Fenton Reaction," J. Environ. Eng. Sci., in press (2005); V. G. Gavalas, M. J. Berrocal and L.G. Bachas, "Enhancing the Blood Compatibility of Ion-Selective Electrodes," Anal. Bioanal. Chem., in press (2005); M. Nakka, R. B. Iyer and L. G. Bachas, "Intersubunit Disulfide Interactions Play a Crucial Role in Maintaining the Thermostability of Glucose-6-Phosphate Dehydrogenase from the Hyperthermophilic Bacterium Aquifex aeolicus," Protein J., in press (2005); B. Sharma, S. K. Deo, L. G. Bachas and S. Daunert, "Competitive Binding Assay Using Fluorescence Resonance Energy Transfer for the Identification of Calmodulin Antagonists," Bioconjugate Chem., in press (2005).