Occupant Detail Information

           Back to faculty list

Name: Daret K.  St. Clair
Position Type: Chair
Appointment Start Date: 09/01/02
Appointment End Date: 08/31/07
Area of Specialty: Oxidative Stress.
Summary Vita:
Highest Degree: Ph.D.
Professional Affiliations: NCI Study Section Member; National Cancer Institute Site Visit Team; Special Emphasis Panel Member NIH; External Advisor to the Comprehensive Cancer Center of Wake Forrest University and the Holden Cancer Center of the University of Iowa; Presentation at the Annual Meeting of the Society of Free Radical Biology and Medicine and the American Association of Cancer Research.
Primary Research Focus: Oxidative stress.
Key Contributions: Discover a novel approach to intervention of oxidative stress-initiated tissue injury.
Publications: (1) Oberley TD, Xue Y, Zhao Y, Kiningham K, Szweda LI, St. Clair DK: In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model. Antioxid. Redox Signal 6:537-548, 2004. (2) Chaiswing L, Cole MP, St. Clair DK, Ittarrat W, Szweda LI, Oberley TD: Oxidative damage precedes nitrative damage in adriamycin-induced cardiac mitochondrial injury. Toxicologic Pathology 32:536-547, 2004. (3) Dhar SK, Lynn BC, Daosukho C, St. Clair DK: Identification of nucleophosmin as an NF-{kappa}B Co-activator for the induction of the human SOD2 Gene. J. Biol. Chem. 279:28209-28219, 2004. (4) Marrecki JC, Cota-Gomez A, Vaitaitis GM, Honda JR, Porntadavity S, St. Clair DK, Flores SC: HIV Tat regulates the SOD2 basal promoter by altering SP1/SP3 binding activity. Free Radic. Biol. Med. 37:869-880, 2004. (5) St. Clair DK: Manganese superoxide dismutase; Genetic variation and regulation. J. Nutr. 134:3190-1S, 2004. (6) Kiningham KK, Daosukho C, St. Clair DK: IkB-a identified as labile repressor of manganese superoxide dismutase (MnSOD) expression. Biochem. J. 384:543-549, 2004. (7) Porntadavity S, Nath A, Prachayasitikul V, Cota-Gomez A, Flores SC, St. Clair DK: Differential roles of Sp family members in HIV-1 tat-mediated superoxide dismutase suppression in hepatocellular cells. DNA and Cell Biology 24:299-310, 2005. (8) Komatsu M, Kuroda M, Wang Y, St. Clair DK, Urano M, Akaki S, Asaumi J, Hiraki Y, Kanazawa S: Manganese superoxide dismutase overexpression changes plating efficiency bidirectionally according to change in redox for SaOS2 human osteosarcoma cell line. Int. J. Oncol. 26:853-862, 2005. (9) Wang Y, Kuroda M, Gao X, Asaumi J, Shibuya K, Kawasaki S, Akaki S, St. Clair DK, Hiraki Y, Kanasawa S: Hydrogen peroxide overload increases adriamycin-induced apoptosis of SaOS2FM, a manganese superoxide dismutase-overexpressing human osteosarcoma cell line. Int. J. Oncol. 26:1291-1300, 2005. (10) St. Clair DK, Zhao Y, Chaiswing L, Oberley T: Modulation of skin tumorigenesis by SOD. Biomedicine & Phyarmacotherapy 59:209-214, 2005. (11) Zhao Y, Chaiswing L, Oberley TD, Batinic-Haberle I, St. Clair WH, Epstein CJ, St. Clair DK: A mechanism based antioxidant approach for the reduction of skin carcinogenesis. Cancer Res. 65:1401-1405, 2005. (12) Zhao Y, Chaiswing L, Velez JM, Batinic-Haberle I, Colburn NH, Oberley TD, St. Clair DK: p53 Translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein - manganese superoxide dismutase. Cancer Res. 65:3745-3750, 2005. (13) Chaiswing L, Cole MP, St. Clair DK, Ittarrat W, Szweda LI, Oberley TD: Early mitochondrial oxidative/nitrative damage in Adriamycin-induced cardiac injury. Molecular Cancer Therapeutics 4:1056-1064, 2005. (14) Cole MP, Chaiswing L, Oberley TD, Lin S-M, Kiningham KK, St. Clair DK: The protective roles of nitric oxide (NO) and superoxide dismutase (SOD) in Adriamycin (ADR)-induced Cardiotoxicity. J. Cardiovascular Res. (in press). (15) Daosukho C, Ittarat W, Lin S-M, Sawyer D, Kiningham KK, Lien Y-C, St. Clair DK: Induction of manganese superoxide dismutase (MnSOD) mediates cardioprotective effect of Tamoxifen (TAM). J. Mol. Cell. Cardiol. (in press). (16) Dhar SK, Lynn BC, Daosukho C, St. Clair DK: Nucleophosmin, a novel transcription co-activator of MnSOD gene in Vitro and in Vivo. Free Radic. Biol. Med. S 62, 2004 (Abstract). (17) Sompol P, Ittarat W, Xu Y, St. Clair D: The neuroprotective effect of tumor necrosis factor alpha: role of NF-kB signaling pathway. Free Radic. Biol. Med. S 72, 2004 (Abstract). (18) Lien Y-C, Noel T, Nithipongvanitch R, Oberley T, St. Clair DK: TNF receptors suppress the Fas-mediated pathway and protect against Adriamycin-induced intrinsic cell death pathway in cardiomyocytes. Free Radic. Biol. Med. S 118, 2004 (Abstract). (19) Cole MP, Chaiswing L, Oberley T, Kiningham K, St. Clair D: Overexpression of MnSOD suppresses p53-mediated ADR-induced cardiac injury in mice lacking iNOS. Free Radic. Biol. Med. S 132, 2004 (Abstract). (20) Josson S, Xu Y, St. Clair D, St. Clair W: Selective inhibition of RelB suppresses tumorigenecity and intrinsic radiation sensitivity of prostate cancer cells. Free Radic. Biol. Med. S 135, 2004 (Abstract). (21) Tangpong J, Sultana R, Joshi G, Cole M, Estus S, Vore M, Ratanachaiyawong S, St. Clair W, St. Clair D, Butterfield A: Adriamycin-induced central nervous system toxicity: An insight into the mechanism of chemobrain. Free Radic. Biol. Med. S 164, 2004 (Abstract). (22) Velez JM, Kiningham KK, Zhao Y, Oberley T, St. Clair D: Interaction between MnSOD and p53 reveals a mitochondrial-mediated mechanism of Taxol induced peripheral neuropathy. Free Radic. Biol. Med. S 164, 2004 (Abstract). (23) Zhao Y, Chaiswing L, Velez JM, Batinic-Haberle I, Colburn NH, Oberley TD, St. Clair DK: p53 Translocation to mitochondria precedes its nuclear translocation and targets the mitochondrial oxidative defense protein manganese superoxide dismutase. Free Radic. Biol. Med. S 170, 2004 (Abstract). (24) Muthuswamy A, Tangpong J, Kiningham K, Flood D, Markesbery WR, St. Clair DK: Meta-amyloid mediated nitration of MnSOD:Implication for oxidative stress in a double knock-in mouse model of Alzheimer's Disease. OVSOT (Lexington, KY), 2004 (Abstract).