||Bradley D. Anderson
|Appointment Start Date:
|Appointment End Date:
|Area of Specialty:
||Bradley D. Anderson received a B.A. in chemistry (1971) and M.S. and Ph.D. degrees in Pharmaceutical Chemistry (1978) from the University of Kansas. He was a research scientist at The Upjohn Company for 5 years prior to joining the University of Utah in 1983 where he was a Professor of Pharmaceutics & Pharmaceutical Chemistry until March of 2000. He then relocated to the University of Kentucky where he served as Chair of the Division of Pharmaceutical Sciences until 2003.
||Membership in Scientific and Professional Societies:
1. Phi Lambda Upsilon
2. Rho Chi
3. American Chemical Society
4. American Association for the Advancement of Science
5. American Association of Pharmaceutical Scientists
6. Biophysical Society
T.-X. Xiang and B.D. Anderson, “Distribution and Diffusion of Water and Their Effects on Molecular Mobility in Poly(Vinylpyrrolidone) Glass: A Molecular Dynamics Simulation”, 2005 AAPS Meeting and Exposition, Nashville, TN, Nov. 2005.
B.D. Anderson, “Drug Stability in Amorphous Solids: Insights from Molecular Dynamics”, 2005 AAPS Meeting and Exposition, Nashville, TN, Nov. 2005.
Dayong Luo and B.D. Anderson, “Kinetics and Mechanism of the Reaction of Cysteine with Hydrogen Peroxide in Amorphous PVP Lyophiles – Comparison to the Aqueous Solution Reaction”, 2005 AAPS Meeting and Exposition, Nashville, TN, Nov. 2005.
T.-X. Xiang, Z. Jiang, L. Song, and B.D. Anderson, “Molecular Dynamics Study of 7-t-Butyldimethylsilyl-10-Hydroxycamptothecin (DB-67) and its 20-Aminobutyrate Ester (DB67-AB) in DMPC Membranes Compared with Experiment”, 2005 AAPS Meeting and Exposition, Nashville, TN, Nov. 2005.
B.D. Anderson, “Early Stage Development of DB-67, A Highly Lipophilic Camptothecin Analog, and Liposomal Prodrug Design for Improved Tumor Delivery”, AAPS - Northeast Regional Discussion Group Meeting, Rocky Hill, CT, April, 2006.
B.D. Anderson, “Can We Predict Lipid Bilayer Permeability Quantitatively? Insights from Experiments and Molecular Dynamics Simulation”, 38th Higuchi Research Seminar, Lawrence, KS, May, 2006
1. 1994 – 1998; Associate Editor, Journal of Pharmaceutical Sciences 2003- present
2. 1987 – 1994; Editorial Advisory Board, Pharmaceutical Research. 2000 – present
3. 1995 - present; Editorial Advisory Board, Pharmaceutical Development and Technology
4. 1999 - present; Editorial Advisory Board, Biopharmaceutics and Drug Disposition
5. 1999 - present; Editorial Advisory Board, AAPS PharmSci
6. 2001 - present; Editorial Advisory Board, Journal of Pharmaceutical Sciences
|Primary Research Focus:
||Dr. Anderson’s main research focus is in the development of new camptothecin antitumor agents.
||Dr. Anderson has contributed to camptothecin antitumor agents, drug delivery to tumors and the brain, drug preformulation and formulation, solid-state stability of drug molecules, lipid bilayer membrane permeability, and molecular dynamics simulations of drug molecules in lipid bilayer membranes and in amorphous polymers.
||D. Luo, S.W. Smith, and B.D. Anderson, Kinetics and mechanism of the reaction of cysteine and hydrogen peroxide in aqueous solution, J. Pharm. Sci., 94, 304-316 (2005).
Burke, T.G., T.-X. Xiang, B.D. Anderson, and L.J. Latus. “Recent Advances in
Camptothecin Drug Design and Delivery Strategies” in Camptothecins in Cancer Therapy, T.G. Burke and V.R. Adams, Eds., Humana Press, Inc., New Jersey (2005).
J.E. Edwards, J. Alcorn, J. Savolainen, B.D. Anderson, and P.J. McNamara, Role of p-glycoprotein in distribution of nelfinavir across the blood-mammary tissue barrier and blood-brain barrier, Antimicrob. Agents Chemother., 49, 1626-28 (2005).
T.-X. Xiang and B.D. Anderson, Distribution and effect of water content on molecular mobility in poly(vinylpyrrolidone) glasses: A molecular dynamics simulation, Pharm. Res., 22, 1205-1214 (2005).
T.-X. Xiang and B.D. Anderson, Conformational structure, dynamics and solvation energies of small alanine peptides in water and carbon tetrachloride, J. Pharm. Sci., 95, 1269-1287 (2006).
B.D. Anderson and D. Luo, Application of an exact mathematical model and the steady-state approximation to the kinetics of the reaction of cysteine and hydrogen peroxide in aqueous solution: A reply to the Ashby and Nagy commentary, J. Pharm. Sci., 95, 19-24 (2006).
B.D. Anderson, M.J. Crump, S. Jordan, L. Song, M.J. Roberts, and M. Leggas, Dependence of nelfinavir brain uptake on dose and tissue concentrations of the selective P-glycoprotein inhibitor zosuquidar in rats, Drug Metab. Disp. 34, 653-659 (2006).