University of Kentucky Research

What are GRPs / GLPs?

GRPs
It is the center’s mission to support researchers through the development and support of Good Research Practices (GRPs). GRPs embody study planning, conduct, and reporting principles that share the intent of federal regulations (GLPs, see below).

Good Research Practices (GRPs) support:
  • Meeting updated NIH/NSF and journal requirements for conducting and reporting research1-7
  • Increased confidence in decisions based on reliable data
  • Accessing industry partnerships more readily, and earlier

GRP PrinciplesScientific Quality

1 Collins, F. S. & Tabak, L. A. Policy: NIH plans to enhance reproducibility. Nature 505, 612-613 (2014).
2 Principles and Guidelines for Reporting Preclinical Research
3 Enhancing Reproducibility through Rigor and Transparency
4 McNutt, M. Journals unite for reproducibility. Science 346, 679 (2014).
5 Editorial. Journals unite for reproducibility. Nature 515, 7, doi:10.1038/515007a (2014).
6 Landis, S. C. et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature 490, 187-191, doi:10.1038/nature11556 (2012).
7 NSF Reproducibility Framework. (2014).

Click on topic for more information about GRPs.

GLPs
The GRP Resource Center has experience implementing Good Laboratory Practices (GLPs) - federal regulations that describe the minimum requirements for conducting non-clinical studies that support or are intended to support research or marketing permits for products regulated by the Food and Drug Administration (FDA) or Environmental Protection Agency (EPA).

The primary intent of the GLPs is to ensure data quality, integrity and reproducibility. To support this intent, the GLPs direct several conditions under which studies are initiated, planned, performed, monitored, recorded and reported. GLP elements are core components for conducting reproducible research that can be adapted to establish guidelines for Good Research Practices (GRPs).

1 CFR - Code of Federal Regulations Title 21. Part 58 Good Laboratory Practice for Nonclinical Laboratory Studies
2 CFR - Code of Federal Regulations Title 40, Parts 160 and 792 Good Laboratory Practice Standards