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Gill Institute Researcher Wins Prestigious Award

Photo of Dennis BruemmerDennis Bruemmer has received the 2005 Irvine Page Award for Young Investigators from the American Heart Association. A UK assistant professor of medicine in the Division of Endocrinology and Molecular Medicine, Bruemmer came to the University of Kentucky from the University of California, Los Angeles, and is also a faculty member of the UK Gill Heart Institute Cardiovascular Research Center.

His current research is focused on understanding the mechanisms leading to diabetic vascular complications. “In my lab, we are focused on characterizing how specific proteins in the nucleus of the cell regulate cell functions and thereby prevent the development of cardiovascular disease in diabetes,” Bruemmer explains. “Understanding these mechanisms is important because the nuclear receptors involved can be activated by drugs already clinically used to treat insulin-resistance in patients with type 2 diabetes, a common cardiovascular risk factor.”

Cardiovascular disease is the leading cause of death in the nation, accounting for nearly half of all deaths. Diabetes is associated with significantly accelerated rates of cardiovascular complications. According to the Center for Disease Control and Prevention, over 18.3 percent of all Americans 60 or older had diabetes in 2002 and an estimated 65 percent of patients with diabetes ultimately die from cardiovascular causes.

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