Division of Laboratory Animal Resources (DLAR)

Animal Health and Veterinary Information

Information concerning the current health status can be accessed by logging into the University of Kentucky Blackboard system. If you are unable to view the ESSENTIAL INFORMATION FOR RESEARCHERS WORKING WITH ANIMALS Please email our training coordinator for enrollment information

As our site continues to expand, we have included in this section a table of commonly used analgesics and their dosages for rabbits and rodents, as well as other species. We have included in this section recommendations, guidelines and information on various topics relating to the overall health and well being of research animals

UK Researcher Guide for the Use of DEA Controlled Substances
2013 Rodent CO2 Euthanasia Guidelines

Recommended Anesthesia for Some Laboratory Animal Species
A Good, Safe Rabbit Pre-med Anesthsia
Open-Drop or Nose Cone Method of Isoflurane Anesthesia in Mice and Rats
Preparation and Use of Tribromoethanol or Avertin
Guidelines for Procedures in Animal Housing Rooms
DLAR Guidelines for Blood Collection in Laboratory Animals
Tumor Models in Rodents
DLAR Guidelines for Acclimation Periods for Newly Received Laboratory Animals
Implantation of Osmotic Pumps in Rodents

Tissue Collection (Biopsy) for Genetic Identification of Rodents
Care of weanling mice and rat pups
Malocclusion in the Laboratory Mouse a Jackson Labs JAX ® NOTES article
Hydrocephalus in Laboratory Mice a Jackson LabsJAX ® NOTES article
Markers for Heightened Monitoring, Imminent Death, and Euthanasia in Aged Inbred Mice - Comparative Medicine Vol 62, No 3 June 2012 Pages 172–178
Ulcerative Dermatitis in C57BL/6 Mice Exhibits an Oxidative Stress Response Consistent with Normal
Wound Healing
- Comparative Medicine Vol 62, No 3 June 2012 Pages 166-171
Aggression In Labe Mice

If there are any questions, please consult with one of our health care staff and our DLAR veterinarians should you require assistance.

Non-steroidal and Opioid Analgesics for Rodents and Rabbits

Analgesic Class of Drug Mouse Rat Guinea Pig Gerbil Hamster Rabbit
Acetaminophen NSAID 300 mg/kg PO 100-300 mg/kg PO (6 mg/ml drinking water)

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100-300 mg/kg PO (6 mg/ml drinking water) 100-300 mg/kg PO (6 mg/ml drinking water) 1 ml drug/100ml drinking water
Carprofen NSAID 10.0 mg/kg SC or PO q 12-24 hours 5-7 mg/kg SC or PO q 12-24 hours 2.5 mg/kg SC q 24 hours 5.0-10.0 mg/kg SC or PO q 12-24 hours 5.0-10.0 mg/kg SC or PO q 12-24 hours 1.5-5 mg/kg PO, or 4 mg/kg SC q 24 hours
Flunixin NSAID 2.5 mg/kg SC q 12 hours 1.1-2.5 mg/kg SC q 2 hours 1.1-2.5 mg/kg SC q 2 hours 1.1-2.5 mg/kg SC q 2 hours 1.1-2.5 mg/kg SC q 2 hours 1.1 mg/kg SC or IM q 12 hours
Ketoprofen NSAID ____________ 5.0 mg/kg IM q 12-24 hours ____________ 5.0 mg/kg IM q 12-24 hours 5.0 mg/kg IM q 12-24 hours 3.0 mg/kg IM q 24 hours
Meloxicam NSAID 2-5 mg/kg IP q 12-24 hours 1-4 mg/kg SC or IP q 24 hours 1-2 mg/kg SC or PO q 24 hours 1.0 mg/kg SC or PO q 24 hours 1.0 mg/kg SC or PO q 24 hours 0.3-0.6 mg/kg SC or PO q 24 hours
Buprenorphine Opioid 0.05-0.1 mg/kg  SC q 3-5 hours **see below 0.01-0.05 mg/kg SC q 6-8 hours **see below 0.05 mg/kg SC q 6-12 hours 0.1-0.2 mg/kg SC q 6-12 hours 0.05-0.5 mg/kg SC q 6-12 hours 0.02-0.1 mg/kg IV or SC q 6-12 hours

Buprenorphine SR (sustained release)

Opioid

 

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Oral Buprenophine in Nutella Opioid Formula and Preparation for Administration to Mice and Rats        
Oral Buprenophine in ClearH2O Medigel Sucralose and Hazelnut flavor Medigel Opioid Formula and Preparation for Administration to Mice and Rats        
Nalbuphine Opioid 4-8 mg/kg IM q 4 hours 2-5 mg/kg IM q 4 hours 1-2 mg/kg IM q 4 hours 1-2 mg/kg IM q 4 hours 1-2 mg/kg IM q 4 hours 1-2 mg/kg IM or IV q 4 hours
Meperidine (Demerol) Opioid 10-20 mg/kg SC or IM q 2-3 hours 10-20 mg/kg SC or IM q 2-3 hours 10-20 mg/kg SC or IM q 2-3 hours 10-20 mg/kg SC or IM q 2-3 hours 10-20 mg/kg SC or IM q 2-3 hours 5-10 mg/kg SC or IM q 2-3 hours

Other analgesics and multimodal combinations of analgesics can be used. Please consult with a DLAR veterinarian for further details.
** Contact our DLAR Veterinarians for further information if needed
*** Dose depending on pain severity DLAR recommends that you access the link provided here for further information on Dosing of Buprenophine SR-Lab

DLAR also recommends giving Injectable analgesic during surgery or at the beginning of surgery to allow time for the analgesic to begin working before the animal would be perceiving pain.  Preferably allow 30 minutes to one hour.

REFERENCES

  • Anesthesia and Analgesia in Laboratory Animals, Second Edition,  Richard E Fish, Marilyn J Brown, Peggy J Danneman, Alicia Z Karas (eds.) American College of Laboratory Animal Medicine Series,  2008.
  • Formulary for Laboratory Animals, Third Edition, Compiled by C Terrance Hawk, Steven L Leary, Timothy H Morris, American College of Laboratory Animal Medicine and European College of Laboratory Animal Medicine, Blackwell Publishing, 2005.
  • Formulary for Laboratory Animals, Second Edition, Compiled by C Terrance Hawk, Steven L Leary, Timothy H Morris, American College of Laboratory Animal Medicine and European College of Laboratory Animal Medicine, Blackwell Publishing, 1999.
    ZooPharm Formulation for: Pain Management in Laboratory Animals Information Sheet Buprenophine SR™ Lab


Other Species

Non-steroidal and Opioid Analgesics for Large Laboratory Animal Species

Analgesic Class of Drug Ferret Cat Dog Pig Sheep NHP
Carprofen NSAID 2-4 mg/kg PO or SC q 24hrs 4.0 mg/kg SC or IV once only 2.0 mg/kg SC or IV q12 hrs or 4.0 mg/kg SC or IV q24 hrs. 2.0-4.0 mg/kg SC or IV q 24h for 2-3 days 1.5-2.0 mg/kg SC or IV q 24h for 2-3 days 2.0-4.0 mg/kg SC or PO q 24 hrs up to 4 days
Flunixin NSAID 0.3 mg/kg PO or SC q 24hrs 1.0 mg/kg IV or IM q 24 hrs 1.0 mg/kg IV or IM q 24 hrs 1.0-2.2 mg/kg IV or SC q 24 hrs 1.5-2.0 mg/kg IV or SC q 24 hrs 2.0-4.0 mg/kg SC or IV q 24 hrs
Ketoprofen NSAID 1-2 mg/kg PO or SC q 24hrs 2.0 mg/kg SC q 24 hrs up to 3 days 2.0 mg/kg SC q 24 hrs up to 3 days 3.0 mg/kg SC only once 1.0 mg/kg IM q 24hrs for up to 3 days NA
Meloxicam NSAID 0.2 mg/kg PO or SC q 24hrs 0.2 mg/kg SC or PO on first day of treatment, then 0.1 mg/kg q 24 hrs 0.2 mg/kg SC or PO q 24 hrs 0.2-0.3 mg/kg SC or PO q 24 hrs NA 0.2-0.3 mg/kg PO q 24 hrs up to 4 days
Buprenorphine Opioid 0.01-0.03 mg/kg IM, SC, or IV q 8-12 hrs 0.005-0.01 mg/kg IM, SC, or IV q 8-12 hrs 0.005-0.02 mg/kg IM, SC, or IV q 6-12 hrs 0.005-0.02 mg/kg IM, SC, or IV q 6-12 hrs 0.005-0.01 mg/kg IM, SC, or IV q 6-12 hrs 0.01-0.02 mg/kg IM, or SC q 6-12 hrs
Butorphanol Opioid 0.2-0.8 mg/kg IM or SC q 2 hrs 0.2-0.4 mg/kg IM, or IV q 3-4 hrs 0.2-0.4 mg/kg IM, or IV q 3-4 hrs 0.1-0.3 mg/kg IM q 4-6 hrs 0.5 mg/kg SC q 2-3 hrs 0.05 mg/kg IM q 6-8 hrs
Morphine Opioid 0.5-2 mg/kg IM or SC q 4-6 hrs 0.1 mg/kg IM q 4 hrs 0.5-5.0 mg/kg IM q 4 hrs 0.2-1.0 mg/kg IM q 4 hrs 0.1-2.0 mg/kg IM q 4 hrs 0.2-1.0 mg/kg IM q 4 hrs
Pethidine (Meperidine)  Opioid 5-10 mg/kg IM q 2-4 hrs 2-10 mg/kg IM or IV q 2 hrs 6-10 mg/kg IM or SC q 2-3 hrs 2 mg/kg IV q 4 hrs OR 4-10 mg/kg IM 2 mg/kg IM q 2 hrs 2-4 mg/kg IM q 4 hrs
Fentanyl Opiod NA Patch q 72hrs Patch q 72 hrs IV q 4 hrs NA NA

Other analgesics and multimodal combinations of analgesics can be used. Please consult with a DLAR veterinarian for further details.

REFERENCES

  • Anesthesia and Analgesia in Laboratory Animals, Second Edition,  Richard E Fish, Marilyn J Brown, Peggy J Danneman, Alicia Z Karas (eds.) American College of Laboratory Animal Medicine Series,  2008.
  • Formulary for Laboratory Animals, Third Edition, Compiled by C Terrance Hawk, Steven L Leary, Timothy H Morris, American College of Laboratory Animal Medicine and European College of Laboratory Animal Medicine, Blackwell Publishing, 2005.
  • Formulary for Laboratory Animals, Second Edition, Compiled by C Terrance Hawk, Steven L Leary, Timothy H Morris, American College of Laboratory Animal Medicine and European College of Laboratory Animal Medicine, Blackwell Publishing, 1999.