Human Research Projects

Cardiac Study

Cardiac Study

cine, short-axis MR of heart
Cine, short-axis MR image showing the left and right ventricles on a normal volunteer

Cine, short-axis MR image showing the left and right ventricles on a normal volunteer (left). Images were made using a segmented FLASH technique with temporal resolution is 55 msec. Total acquisition time was approximately 15 seconds during which the subject held their breath. 

cine, long-axis MR of heart
Cine, long-axis MR image on the same volunteer as above.

 

 

Cine, long-axis MR image on the same volunteer. In these images, blood appears bright because it passes through the image place unattenuated by previous excitations. Myocardium appears with intermediate image intensity because of repeated excitations. 

short axis view of left and right ventricles
A short axis view of the left and right ventricles in a normal volunteer.

 

 

A short axis view of the left and right ventricles in a normal volunteer. A grid of saturation pulses has been superimposed on the image plane before the start of systole. As the grid is attached to the tissue it demonstrates the deformation of the myocardium during systole and diastole. This technique is useful for visualizing wall motion abnormalities and impairment of ventricular function due to myocardial function, hypertrophic cardiomyopathy and other diseases.

 

 

arthritis

Arthritis

arthritic knee
Arthritic Knee

 

 

 

 

 

 

Brain Imaging Studies

Brain Imaging Studies

Daughter's Study

brain mri
MRI of Brain

This study uses Magnetic Resonance Imaging (MRI) to discover changes in the brain that occur in women who might develop Alzheimer's disease later in life. It is supported by the National Institute of Neurological Disorders and Stroke (NINDS). Healthy women without memory loss between the ages of 40 and 85 years who are familiar with their family medical history are eligible. Participants have MRI scans, donate a blood sample, and have testing of memory as part of the study. There is no cost to the participant, and there is a small payment to offset travel costs and time. LuAnn Hamon, the study coordinator, can provide details regarding eligibility for the study.

Alzheimer's Disease Neuroimaging Initiative (ADNI)

ADNI uses Magnetic Resonance Imaging (MRI) to track changes in the brain by performing scans every six months for three years. It is supported by the National Institute on Aging. A blood sample, neurological examination and memory testing are other parts of the study. Three groups of participants are needed:

  • Healthy persons aged 70–90 years without significant memory loss
  • Persons with Mild Cognitive Impairment (MCI) ages 55–90 years. MCI is a condition of mild but definite memory loss without significant impairments in day-to-day activities
  • Persons with early (mild) Alzheimer's Disease

There is no cost to the participant, and there is a small payment to offset travel costs and time. LuAnn Hamon, the study coordinator, can provide details regarding eligibility for the study. 

Ventral Processing

Ventral Processing Stream

Ventral mri

 

 

 

 

 

Lexical Semantics

Dissociation of Automatic & Strategic Lexical-Semantics

lexical-semantics

"Behavioral research has demonstrated three major components of the lexical-semantic processing system: automatic activation of semantic representations, strategic retrieval of semantic representations, and inhibition of competitors. However, these component processes are inherently conflated in explicit lexical-semantic decision tasks typically used in functional magnetic resonance imaging (fMRI) research. Here, we combine the logic of behavioral priming studies and the neurophysiological phenomenon of fMRI priming to dissociate the neural bases of automatic and strategic lexical-semantic processes across a series of three studies." 

B.T. Gold, et al. Dissociation of Automatic and Strategic Lexical-Semantics: Functional Magnetic Resonance Imaging Evidence for Differing Roles of Multiple Frontotemporal Regions. The Journal of Neuroscience. 2006 26(24):6523-6532 (pdf, 10pgs)

Visual Cognition

Visual Cognition of the Brain

visual cognition and brain regions

Dr. Jiang's Aging Brain and Cognition Lab – Behavioral Science

http://www.mc.uky.edu/mrisc/yanglab/data/main.asp

Study 1 - Neuroimaging (fMRI) of visual memory in older and mild cognitive impairment adults 
One hour MRI scans investigate how visual memory changes with age and in degenerative disease states like Alzheimer’s and mild cognitive impairment. Subjects will be compensated for their time commitment and travel to complete the study.

Study 2 - Alzheimer’s disease detection via nonlinear analysis of EEG 
EEG is a routine medical tool that carries no adverse effects and may serve as one of the best diagnostic tools for detecting early memory and cognitive changes. Subjects with normal memory and thinking, mild cognitive impairment, early Alzheimer’s disease and Dementia with Lewy Bodies are being recruited for this study.

For more information or to enroll, call the Aging Brain and Cognition Lab at 859-323-7263.